Start Submission Become a Reviewer

Reading: Erythrocyte uptake of drugs and its impact on volume of distribution (VD) determinations

Download

A- A+
dyslexia friendly

Research Papers

Erythrocyte uptake of drugs and its impact on volume of distribution (VD) determinations

Authors:

W. Pathirana ,

Department of Pharmacology and Pharmacy, Faculty of Medicine, University of Colombo, LK
X close

D. Chandrarathna,

Department of Chemistry, Faculty of Science, University of Colombo, LK
X close

N.N. Wickremasinghe,

Bachelor of Pharmacy Program, Faculty of Medical Sciences, University of Sri Jayewardenepura, LK
X close

P.C. De Silva,

Bachelor of Pharmacy Program, Faculty of Medical Sciences, University of Sri Jayewardenepura, LK
X close

P. Zoysa,

Department of Biochemistry and Molecularbiology, Faculty of Medicine, University of Colombo, LK
X close

N.R. Samaranayake,

Bachelor of Pharmacy Program, Faculty of Medical Sciences, University of Sri Jayewardenepura, LK
X close

M.D.J. Wijayabandara

Bachelor of Pharmacy Program, Faculty of Medical Sciences, University of Sri Jayewardenepura, LK
X close

Abstract

In most volume of distribution (VD) determinations the drug partitioned in to erythrocytes (Cery) occupying 45% of blood volume is disregarded. The VD determinations can be erroneous on two accounts. The first is the indiscriminate reference to plasma (Cp), whole blood (Cb) or serum (Cs) concentrations. The second is when Cery values are not considered in calculations. Isolated erythrocytes were incubated in plasma water (Cpw) represented by physiological saline drug solutions, the Cpw, Cery and Cb values were experimentally determined in vitro. Aberrations to the VD determinations are demonstrated using both theoretically and practically determined values of Cpw, Cery and Cb. Widely varying VD values 125 L to 2.55 L resulted when Cp data alone is used while the values differed marginally from 4.56 L to 5.53 L when Cb values were used for two setting using same amount of drug.

DOI: http://doi.org/10.4038/pjsl.v5i0.4
How to Cite: Pathirana, W. et al., (2015). Erythrocyte uptake of drugs and its impact on volume of distribution (VD) determinations. Pharmaceutical Journal of Sri Lanka. 5, pp.16–24. DOI: http://doi.org/10.4038/pjsl.v5i0.4
Published on 01 Nov 2015.
Peer Reviewed

Downloads

  • PDF (EN)

    comments powered by Disqus