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Research Papers

Formulation and Evaluation of Eplerenone Matrix Tablets using Aloe Vera, Guar Gum and Povidone K-30

Authors:

P. Bharghava Bhushan Rao ,

V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, IN
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A. Lakshmana Rao,

V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, IN
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K. Ravi Kumar,

Hindu College of Pharmacy, Guntur, Andhra Pradesh, IN
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K. Sowmya,

V. V. Institute of Pharmaceutical Sciences, Gudlavalleru, Andhra Pradesh, IN
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S. Kameswara Rao

Nirmala College of Pharmacy, Mangalagiri, Andhra Pradesh, IN
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Abstract

Purpose: In the existing work different sustained release matrix tablets of eplerenone were prepared with dried mucilage of Aloe vera, guar gum and povidone K30 by using different binder: tablet weight ratios viz. 1:20, 2:20, 3:20, 4:20 and 5:20.

 

Method: During this process Aloe vera leaves are procured, extracted, dried and characterized to obtain Aloe vera mucilage powder. Pre-formulation studies were performed and studied for the functional groups and also compatibility studies were conducted. The formulations that were prepared using Aloe vera were named as EPA, for Guar gum as EPG, for Povidone K30 as EPP and finally combination of Aloe vera and Povidone K30 was named as EPAP.

 

Results: From the graphs, kinetic evaluation was done and observed that the drug release is governed by diffusion mechanism and this is confirmed by r values. The regression coefficient values, clearly indicates that the drug release is governed by zero order and almost all formulations showing Fickian release. Among all the formulations that were prepared EPAP-5 is selected as best. The best formulation is compared with the marketed formulation.

 

Conclusion: Aloe vera gel dried powder is a suitable matrix agent in formulating sustained release tablets of eplerenone. It may be useful in similar preparations of other drugs.

How to Cite: Rao, P.B.B., Rao, A.L., Kumar, K.R., Sowmya, K. and Rao, S.K., 2018. Formulation and Evaluation of Eplerenone Matrix Tablets using Aloe Vera, Guar Gum and Povidone K-30. Pharmaceutical Journal of Sri Lanka, 8(1), pp.49–60. DOI: http://doi.org/10.4038/pjsl.v8i1.24
Published on 16 Nov 2018.
Peer Reviewed

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